Regenera Activa — Istanbul

A non-surgical option for
selected early-stage thinning.

Regenera Activa uses micrografts taken from your own scalp to support weakened, miniaturised follicles. At Pure Line Clinic, we consider it only when there is still enough existing hair worth supporting.

Regenera Activa treatment at Pure Line Clinic Istanbul
1session
Usually completed in 60–90 minutes
Non-surgical
Injection-based treatment
Autologous
Uses tissue taken from your own scalp
Best window
Early thinning with follicles still present
Understanding the treatment

A treatment based on
your own scalp tissue.

No surgery. No added synthetic material. Regenera Activa is a CE-marked device procedure. A small tissue sample is taken from your scalp, processed into a micrograft suspension, and injected into selected thinning areas. There is no foreign material and no graft implantation.

From your own scalp

The tissue sample, cells, and growth factors all come from you. Because the material is autologous, systemic reactions are considered uncommon in suitable patients.

Support, not replacement

Regenera Activa does not create new follicles. It may support follicles that are still present but weakened. The treatment is most useful when there is still something meaningful to support.

The procedure

What happens
during the session.

The entire procedure takes 60 to 90 minutes and is performed under local anaesthetic. You leave the same day.

1

Tissue harvest

A small sample of scalp tissue is taken from behind the ear or the nape of the neck using 2.5mm micro-punches. Local anaesthetic is applied first.

3 to 4 micro-punches, each 2.5mm
Behind the ear or nape — areas usually chosen for more stable follicular units
Harvest site heals within a few days
Takes approximately 15 minutes
2

Processing

The tissue is processed in the Regenera Activa device to prepare a micrograft suspension from your sample.

Closed processing system
No added synthetic material
Prepared during the same session
Takes approximately 20 to 30 minutes
3

Injection

The prepared micrograft suspension is injected across the thinning scalp using a mesotherapy technique — small injections at the correct dermal depth.

Multiple small injections across the thinning areas
Targeted at the level where follicles sit
Mild discomfort — no general anaesthesia
Patients usually leave shortly after completion
What the evidence suggests

Encouraging data,
with the right limits.

Published studies on autologous cellular micrografts report improvement in selected androgenetic alopecia patients. The evidence is promising, but it does not mean every patient will respond — and it does not make Regenera Activa a replacement for hair transplantation when follicles are already lost.

Journal of Clinical and Aesthetic Dermatology

Measurable changes in selected AGA patients

Some clinical studies have reported improvement in hair density and shaft diameter in selected androgenetic alopecia patients, especially where miniaturised follicles were still present.

Stem Cell Research and Therapy

Support for weakened follicles

Research suggests that scalp-derived cellular micrografts may support the local environment around weakened follicles during the growth cycle.

International Journal of Dermatology

Safety in suitable patients

Published reports describe a favourable safety profile in selected patients, with the autologous approach generally reported as well tolerated.

Why patient selection matters

What it can and
cannot do.

What it may help

Support miniaturised follicles that are still present. Help improve hair calibre and scalp coverage when the biological environment responds. In selected early-stage cases, it may also help reduce the visible progression of thinning.

What it cannot do

Replace follicles that are already gone. Reverse advanced baldness. Guarantee a specific outcome — response varies between patients and depends on the stage of hair loss at the time of treatment.

What to expect

The response
is gradual.

Regenera Activa does not produce an immediate visible result. The biological changes develop over months. This is expected, because the goal is to support existing follicles gradually.

Phase 1
First weeks
The scalp settles. Mild redness or sensitivity after the injections is normal. No visible change is expected at this stage.
Phase 2
Month 1–3
Shedding may begin to slow. Some patients notice early changes in hair texture or calibre. Changes may be happening before they are easy to see.
Phase 3
Month 6–12
Results, when present, become easier to see. Improvement usually appears as stronger, thicker existing hair rather than new density.
Honest comparison

Regenera Activa
vs PRP.

Both are non-surgical and use material from the patient. The difference is not simply stronger or weaker. They work through different biological approaches.

Factor Regenera Activa PRP Therapy
Source material Scalp micrografts Patient's blood
Main biological focus Micrograft-based follicle support Platelet-derived growth factor support
Typical protocol Usually one session Usually a series of sessions
Best suited for Selected early thinning with miniaturised follicles Supportive treatment in selected shedding or thinning cases
Role around surgery May be considered as an adjunct May be considered as an adjunct
Limit Does not create new follicles Does not create new follicles
Patient selection

Who may benefit — and
who should wait.

Good outcomes depend on careful selection. We do not offer Regenera Activa to everyone who asks.

Who may benefit

Early-stage androgenetic alopecia

The treatment works best when miniaturised follicles are still present. Earlier stages usually leave more follicles to support.

Thinning that is progressing slowly

Patients with stable or slowly progressing loss tend to respond better than those with rapid, aggressive thinning.

Men and women with pattern hair loss

May be considered in selected men and women with pattern hair loss after medical evaluation.

Alongside medical treatment

It may be discussed alongside treatments such as minoxidil or finasteride when appropriate. Medication suitability, side effects, and follow-up should always be reviewed by a physician.

After hair transplant surgery

In some cases, Regenera Activa may be used after hair transplant surgery to support the native follicles that remain.

Who should wait

Advanced baldness — no remaining follicles

If the follicles are already gone, there is nothing for the treatment to support. Hair transplantation may be the more realistic option, if the donor area is suitable.

Rapid, aggressive hair loss

When thinning is progressing quickly, it may be better to stabilise the loss first.

Active scalp conditions

Psoriasis, seborrheic dermatitis in active flare, or any infection must be resolved before treatment.

Current cancer treatment

Patients receiving or recently completing chemotherapy or radiotherapy should not proceed. A clearance period is required.

Pregnancy and breastfeeding

The procedure is not appropriate during pregnancy or breastfeeding. Post-partum shedding should stabilise before reassessment.

After your session

Simple aftercare.
The first two days matter.

Most patients return to normal daily activity the same day. There are a few simple guidelines for the first 24 to 48 hours.

No water on the scalp for 24 hours

Avoid washing your hair or getting the scalp wet on the day of treatment. Normal showering resumes the following day.

No styling products for 48 hours

Gels, sprays, and dry shampoo should be avoided for the first 48 hours. Keep the scalp clean and unobstructed.

Limit sun exposure

Avoid direct sun on the treated scalp for 24 hours. A hat is sufficient.

Gentle handling only

Do not rub, scratch, or apply pressure to the scalp for the first 48 hours. The micro-injection points are small and heal quickly.

If there are follicles still worth supporting,
this is the stage to assess.

Regenera Activa is not the right treatment for everyone. But for patients with early-stage thinning and follicles that are still present, it is worth an honest conversation. Send your photos and a brief description of what you are noticing. We will tell you clearly whether this is appropriate for your case.

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